Simparica for Dogs: Everything You Need to Know About Simparica Trio

Key Takeaways: –
- This is the first FDA-approved product of its kind. It kills six different types of ticks, including deer ticks that tend to carry Lyme disease.
- Protects dogs against heartworms, fleas & ticks, hookworms & roundworms.
- Proven safe to administer to puppies of the age of 8 weeks and weighing at least 2.8 lbs.
If you are a dog owner or dog parent like me, then you are well aware of the importance of tick and flea prevention. Those blood-sucking parasites are quite dangerous for your pet, since they attach to animals, like dogs and cats, and end up feeding on blood.
They are known to reproduce fast and can transmit diseases to your dog’s immune system, making it vulnerable to multiple illnesses.
One of the most effective ways of getting rid of these blood-sucking parasites and protecting your dogs is by using preventive medication such as Simparica.
I have personally used this medication and gotten great results with my 3-year-old Indian Hound dog, Bruno.
But just because I have used it and got positive results is not enough to put your pup in danger. You should do your own research on Simparica, its uses and dangers.
If you keep on scrolling, here is a detailed overview and research of the medications Simparica and Simparica Trio that might be helpful for you.
What are Simparica Products? How are They Used for Fleas, Ticks and Heartworms?

Zoetis manufactures the preventive medication Simparica. This line of products includes chewable tablets used to control, prevent, and treat various types of ticks, fleas, and heartworms in dogs.
The Simparica products are all FDA-approved for numerous antiparasitic uses in dogs and other animals, depending on the product being used.
The different parasitic uses include prevention and treatment of various tick and flea infestations, heartworm diseases, roundworm diseases, and hookworm diseases.
Two different types of Simparica tablets are chewable: –
- Simparica (Protection lasts 35 days against fleas and ticks)
- Simparica Trio (Protection lasts 30 days against fleas, ticks, hookworms and roundworms)
Both Simparica and Simparica Trio are chewable tablets for dogs once a month (interval of every 30 days). These tablets are chewable or broken into pieces and given directly in the mouth.
What are the Benefits of Simparica Products in Dogs?
- All Simparica products contain Sarolaner, an FDA-approved treatment for the control of different types of ticks and fleas in dogs.
- Simparica Trio (Sarolaner mixed with pyrantel and moxidectin) is again an FDA-approved medication for ticks, fleas, hookworm, roundworm, and heartworm.
- Simparica for dogs can be administered to puppies and dogs as young as 8 weeks and weighing at least 2.8 pounds (1/3 kg).
- Fleas start dying within 3 hours with Sarolaner, after using a Simparica product, and kill fleas 100% within 24 hours.
- Within 48 hours, there is a 99% effectiveness against ticks after using sarolaner.
What is Simparica Trio?

It is the most effective product for getting rid of insect infestations in dogs. These tablets are fast, powerful, and administered orally. They are specially designed to eliminate harmful infections and parasites. Simparica Trio gives your dog relief within a few hours of taking it.
Do Simparica Products Have Side Effects in Dogs?

The medication Simparica often works well in most pets. Although there are certain rare side effects that you might notice. These generally include:
- Lethargy
- Vomiting
- Loss of appetite
In some rarer cases, certain neurological side effects have also been seen. So, if your dog has a history of seizures or any other neurological diseases, then it is better to inform your vet before giving him Simparica.
These neurological side effects can include:
- Lack of coordination
- Muscle tremors
- Seizures
Monitoring
Before administering Simparica Trio, your pet must test for any existing signs of heartworm infections.
If your dog has existing signs of heartworm infections, then the adult heartworms should treat before giving Simparica Trio since the medication is ineffective against adult heartworms.
When to Call Your Vet?

You should call your vet when you see signs like:
- Showing severe side effects (see the lists above).
- If even after the treatment, your dog’s condition is not improving.
- You suspect or see an overdose.
Interactions with Other Medications
It is always a risk to use multiple medicines at once since it can alter their effects and cause certain side effects.
It has been seen that if used in the right doses, Sarolaner has no significant interactions with other drugs.
But certain medications can interact with the ingredient moxidectin in Simparica Trio, and they are benzodiazepines such as diazepam (Valium), Alprazolam (Xanax), piperazine and levamisole.
Dosage and Application: Ensuring the Safety of Your Pet’s

Simparica products such as Simparica Trio dosage for dogs are divided according to the dog’s weight, so here is a table from which you can get a good idea about the dosage of Simparica for dogs.
Purple | Dogs weigh between 2.6 to 5kg (5.5 – 11 lbs.) |
Turquoise | Dogs weigh between 10.1 to 20 kg (22 – 44 lbs.) |
Brown | Dogs weigh between 40.1 to 60 kg (88 – 132 lbs.) |
Is Simparica Safe for Dogs?
Yes, Simparica products such as Simparica Trio are safe for dogs. It is very effective against getting rid of fleas and various types of tick infestations. You can easily use it for your dog, but it is better to ask your vet before you give this to your dog.
FAQs
Here are a few questions that most people ask that you may also find helpful.
Unlike other similar medications, Simparica doesn’t require feeding. Simparica Trio can easily be given to your dog with or without food. However, it is important that your dog completes a full dosage.
If you are looking for a cheaper alternative to Simparica Trio for your dog’s monthly protection from ticks, fleas, heartworms, and intestinal worms, NexGard SPECTRA is a great choice.
If you miss a dose, a new dose needs to be administered immediately after that. If your dog vomits or spits out a Simparica dose, a replacement dose should take right after that to maintain the monthly dosage of Simparica Trio.
When your puppy is about 8 weeks old and weighs about 2.8 lbs., you are free to administer Simparica Trio to him, but it is always better that you consult your vet beforehand.
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